Enhancement of Cytosine Arabinoside Cytotoxicity by Granulocyte/Macrophage Colony-stimulating Factor and Granulocyte Colony-stimulating Factor in a Human Myeloblastic Leukemia Cell Line
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چکیده
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Production of Recombinant Human Granulocyte-Colony Stimulating Factor by Pichia pastoris
Human granulocyte-colony stimulating factor (hG-CSF) cDNA was expressed in the methylotrophic yeast Pichia pastoris under the control of the alcohol oxidase (AOX1) promoter. An expression vector for hG-CSF secretion was constructed using vector pPIC9. Higher levels of hG-CSF was obtained using a P. pastoris Mut+ (methanol utilization fast) phenotype. The effects of environmental factors such as...
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Background: Human granulocyte colony-stimulating factor (hG-CSF) can serve as valuable biopharmaceutical for research and treatment of the human blood cancer. Transplastomic plants have been emerged as a new and high potential candidate for production of recombinant biopharmaceutical proteins in comparison with transgenic plants due to extremely high level expression, biosafety and many other a...
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ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 1993
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1993.tb00156.x